Breast cancer drug Arimidex Chemical Raw Steroids Anti Estrogen CAS120511-73-1

ArimidexArimidex InfoMolecular formula: C17H19N5Molecular weight: 293.37Molecular Structure: CAS: 120511-73-1Appearance: an off-white color crystalline powderUse: It can be used to the treatment of Breast cancerStandard: Enterprise Standard Package: 25KG/Drum Description: Anastrozoles Arimidex is the aromatas

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Arimidex
Arimidex Info
Molecular formula: C17H19N5
Molecular weight: 293.37
Molecular Structure: 
CAS: 120511-73-1
Appearance: an off-white color crystalline powder
Use: It can be used to the treatment of Breast cancer
Standard: Enterprise Standard 
Package: 25KG/Drum 



Description:
 
Anastrozoles Arimidex is the aromatase inhibitor of choice. Arimidex's mechanism of action - blocking conversion of aromatizable steroids to estrogen - is in contrast to the mechanism of action of anti-estrogens such as clomiphene (Clomid), which block estrogen receptors in some tissues, and activate estrogen receptors in others.

Anastrozoles is an aromatase-inhibiting drug approved for treatment of breast cancer after surgery, as well as for metastasis in both pre and postmenopausal women. The severity of breast cancer is increased by estrogen, as sexhormones cause hyperplasia, and differentiation at estrogen receptor sites. Anastrozoles works by inhibiting the synthesis of estrogen.
 
The trial suggested that anastrozoles is the preferred medical therapy for Postmenopausal women with localized breast cancer that is estrogen receptor (ER) positive.




Applications:

The drug is appropriately used when using substantial amounts of aromatizing steroids, or when one is prone to gynecomastia and using moderate amounts of such steroids. 

Arimidex does not have the side effects of aminoglutethimide (Cytadren) and can achieve a high degree of estrogen blockade, much moreso than Cytadren. 

It is possible to reduce estrogen too much with Arimidex, and for this reason blood tests, or less preferably salivary tests, should be taken after the first week of use to determine if the dosing is correct.

Potent selective triazole aromatase inhibitors, can inhibit the cytochrome P-450 aromatase enzyme which depends blocking the biosynthesis of estrogen, and estrogen to stimulate breast cancer cell growth factors. 

Treatment of breast cancer, especially for those with hormone relapse after adjuvant therapy after menopause for women with advanced breast cancer.





COA:
ItemsStandardResults
DescriptionWhite crystalline powderComplies
IdentificationIRConform with standard IR
HPLCConform with standard HPLC
ReactiveConform
SolubilityFreely soluble in methanol,acetone,ethanol and tetrahydrofuran.And very soluble in acetonitrileComplies
Total Impuritymax.0.5%0.18%
Total Unspecified Impuritymax. 0.2%0.08%
Individual unspecified impurltymax. 0.1%0.05%
Related compound Bmax. 0.2%0.07%
Related compound Cmax. 0.2%0.04%
Related compound Dmax. 0.1%0.05%
Related compound Emax. 0.1%0.06%
Limit of cyclohexanemax. 0.08%ND
Limit of ethylacetatemax. 0.1%0.07%
Melting point81.0~84.0ºC82.5~83.2ºC
Watermax. 0.3%0.21%
Residue on ignitionmax. 0.1%0.07%
Heavy Metalsmax.0.001%Complies
Assay(HPLC)98.0%~102.0%99.80%
StorageCool and dry
ConclusionIt complies to USP32 .




Breast Cancer Drug Arimidex Chemical Raw Steroids Anti Estrogen CAS120511-73-1





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1.How about parcel delivery success rate ?

Our goods packing will not contain any hormone information and can be sent out from different areas of china. At present,the goods customs clearance rate we send to United states and Europe is 99%. As for Canada, Brazil of quite high buckle close rate area, we also have a new way to get through the customs. We also have completely re-send policy to some areas.

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